CG density ( x-axis) is defined as the number of CG dinucleotides in 200 bp windows. Each panel represents a separate feature, and n refers to the number of analyzed CGs (per-strand depth ≥10) within that feature. Heat maps show distinct methylation and CG density patterns for different genomic features in WT ( A) and Tg( fabp10:nras 61K) transgenic zebrafish ( B). Landscape of methylome in WT and Tg( fabp10:nras 61K) transgenic zebrafish (12 mpf). This work indicates that our transgenic zebrafish could be a valuable model, not only for studying liver cancer, but also for exploring new therapeutic targets.
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In summary, our study provides a comprehensive analysis of molecular mechanisms accompanying the progressive nras 61K -induced ICC. Moreover, three potential biomarker genes were hypomethylated in the tumorigenesis of ICC: ehf, epha4 and itgb6. In particular, our result discovered eleven potential biomarker genes of ICC which were conserved between zebrafish and humans. Analysis of DNA methylomes revealed that compared with WT samples, methylated genes in ICC samples were enriched in functions associated with cellular, single-organism and metabolic processes. Transcriptome analysis and gene set enrichment analysis (GSEA) of liver samples of the ICC and WT (wild-type) zebrafish revealed that the genes differentially expressed between the two groups were mainly involved in focal adhesion, chemokine signaling and metabolic pathways. In this study, we successfully constructed an nras 61K -induced ICC model in zebrafish. Arnold, 1921.Intrahepatic cholangiocarcinoma (ICC) is a highly malignant tumor, difficult to diagnose even at an early stage. The embryology of the human thyroid gland including ultimobranchial body and others related. Origin of the ultimobranchial body cyst: T/ebp/Nkx2.1 expression is required for development and fusion of the ultimobranchial body to the thyroid. Solid Cell Nests in Hashimoto’s Thyroiditis Sharing Features with Papillary Thyroid Microcarcinoma. Branchial-like cysts of the thyroid associated with solid cell nests. Solid cell nests of the thyroid: light microscopy and immunohistochemical profile. J Clin Pathol 56(2):142–143, 2003.Ĭameselle-Teijeiro J, Varela-Durán J, Sambade C, Villanueva JP, Varela-Núñez R, Sobrinho-Simoes M. Differential expression of galectin 3 in solid cell nests and C cells of human thyroid. AJCP 137(4):612–618, 2012.įaggiano A, Talbot M, Baudin E, Bidart JM, Schlumberger M, Caillou B. Absence of the BRAF and the GRIM-19 Mutations in Oncocytic (Hürthle Cell) Solid Cell Nests of the Thyroid. Histopathology (epub - ahead of print), 2015.Ĭameselle-Teijeiro J, Ferreira R, Caramés N, Abdulkader I, Máximo V, Soares P, et al.
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Solid cell nests of the thyroid gland: morphological, immunohistochemical and genetic features. Manzoni M, Roversi G, Di Bella C, Pincelli AI, Cimino V, Perotti M, et al. Virchows Archiv für Pathologische Anatomie und Physiologie und für Klinische Medizin.
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Über die Glandula parathyreodeaa, intrathyreoideale Zellhaufen derselben und Reste des postbranchialen Körpers. Pathology of thyroglossal duct: an institutional experience.